0516国际期刊速递丨今日热点肺动脉

TODAY今日发布BMCCardiovascDisordDec01,:19(1)今日发布02篇（共计篇）CardiovascUltrasoundDec01,:17(1)今日发布01篇（共计09篇）JournalofNuclearCardiologyJune01,:26(3)今日发布01篇PediatricCardiologyEarlyRecent,May16,今日发布01篇StrokeEarlyRecent,May16,今日发布17篇CirculationResearchEarlyRecent,May16,今日发布01篇ATVBEarlyRecent,May16,今日发布08篇RECOMMEND推荐阅读01抑制CHK1（检查点激酶1）对肺动脉高压的治疗作用ATVBresearch-articleAliceBourgeois,SébastienBonnet,etc.2小时前等15用户推荐阅读本文ObjectivePulmonaryarterialhypertension(PAH)isadebilitatingdiseaseassociatedwithprogressivevascularremodelingofdistalpulmonaryarteriesleadingtoelevationofpulmonaryarterypressure,rightventricularhypertrophy,anddeath.AlthoughpresentinghighlevelsofDNAdamagethatnormallyjeopardizetheirviability,pulmonaryarterysmoothmusclecells(PASMCs)frompatientswithPAHexhibitacancer-likeproproliferativeandapoptosis-resistantphenotypeaccountingforvascularlumenobliteration.Incancercells,overexpressionoftheserine/threonine-proteinkinaseCHK1(checkpointkinase1)isexploitedtocounteracttheexcessofDNAdamageinsultstheyareexposedto.ThisstudyaimedtodeterminewhetherPAH-PASMCshavedevelopedanorchestratedresponsemediatedbyCHK1toover







































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